Minerals including chromium, magnesium and zinc are associated with healthy glucose metabolism and may be synergistic with biotin. Bis-glycinato oxo vanadium is a bioavailable organic complex of glycine and vanadium. Vanadium promotes healthy glucose metabolism by supporting healthy liver and skeletal muscle function. The water-soluble polyphenol polymers found in CinSulin cinnamon extract promote healthy glucose function, lipid metabolism and blood flow. Momordica charantia, or bitter melon, and Gymnema sylvestre provide traditional support for healthy pancreas and glucose function. Vitamin C maintains healthy red blood cell sorbitol levels. Alpha lipoic acid supports healthy glucose metabolism by promoting healthy mitochondrial function.